Abstract: With Donald Trump on the brink of being sworn in as the new president, relations between U.S. and Russia are also on the verge of rapprochement.  The incoming administration, which sees Moscow as an ally in the fight against the self-proclaimed Islamic State (IS) in Syria, is likely to explore ways of improving relations.  However, the prospects for strategic realignment between Russia and the U.S. in the Middle East and elsewhere, remain unclear. Russia has no willingness or capacity to replace America as a regional hegemon and underwrite political stability there. The uncertain developments on the ground in Syria and the wider region, as well as the responses of local players such as Iran, Turkey and the Gulf countries, will inhibit collective action.  Hence, the relationship is likely to remain transactional. In the longer term, Moscow and Washington may fall back into the familiar cyclical pattern where moments of cooperation are followed by confrontation and conflict.